Monomethyl fumarate

By Targets:	ADC Antibody (2) ADC Cytotoxin (7) ADC Linker (6) Akt (1) Amino Acid Derivatives (1) Amyloid-β (1) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (9) Apoptosis (6) Bacterial (2) Biochemical Assay Reagents (1) c-Met/HGFR (1) Drug Metabolite (3) Drug-Linker Conjugates for ADC (18) EGFR (1) Estrogen Receptor/ERR (2) Fungal (1) GPR109A (3) Isotope-Labeled Compounds (3) Liposome (3) Microtubule/Tubulin (10) Parasite (2) PROTAC Linkers (14) TNF Receptor (1)
By Research Areas:	Cancer (83) Infection (2) Inflammation/Immunology (6) Neurological Disease (5)
Click Chemistry:	DBCO (2) Azide (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103252

Monomethyl fumarate 3 Publications Verification	GPR109A Drug Metabolite	Neurological Disease Inflammation/Immunology
Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-103252S

Monomethyl fumarate-d3 1 Publications Verification	Drug Metabolite GPR109A	Neurological Disease
Monomethyl fumarate-d₃ is a deuterium labeled Monomethyl fumarate. Monomethyl fumarate is the primary metabolite of dimethyl fumarate[1].

HY-103252S1

Monomethyl fumarate-d5	Isotope-Labeled Compounds GPR109A Drug Metabolite	Neurological Disease Inflammation/Immunology
Monomethyl fumarate-d₅ is deuterium labeled Monomethyl fumarate. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].

HY-135584

*Raloxifene 6-Monomethyl* Ether**	Estrogen Receptor/ERR
Raloxifene 6-Monomethyl Ether (Compound 7) is a Raloxifene derivative that inhibits estrogen receptor α. Raloxifene 4-Monomethyl Ether inhibits MCF-7 cells with an IC₅₀ of 250 nM and a pIC₅₀ of 6.6 .

HY-135590

*Raloxifene 4-Monomethyl* Ether**	Estrogen Receptor/ERR
Raloxifene 4-Monomethyl Ether (Compound 37) is a Raloxifene derivative that inhibits estrogen receptor α. Raloxifene 4-Monomethyl Ether inhibits MCF-7 cells with an IC₅₀ of 1 μM and a pIC₅₀ of 6 .

HY-N8931

Monomethyl lithospermate Lithospermic acid Monomethyl ester	Akt	Neurological Disease
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) .

HY-144182S

Metoxuron-monomethyl-d3

Isotope-Labeled Compounds Others

Metoxuron-monomethyl-d₃ is the deuterium labeled Metoxuron-monomethyl[1].

*Metoxuron-monomethyl-d3*	Isotope-Labeled Compounds	Others
Metoxuron-monomethyl-d₃ is the deuterium labeled Metoxuron-monomethyl[1].

HY-N3754

*Dihydropinosylvin monomethyl* ether**	Parasite	Infection
Dihydropinosylvin monomethyl ether is a natrual compound with nematicidal activity. Dihydropinosylvin monomethyl ether can inhibit pine wood nematodes infection .

HY-N6904

*Crocetin monomethyl* ester**	Amyloid-β	Neurological Disease Inflammation/Immunology
Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity . Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway .

HY-33048

Monomethyl auristatin E intermediate-1	Others	Cancer
Monomethyl auristatin E intermediate-1 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-43146

Monomethyl auristatin E intermediate-3	Others	Cancer
Monomethyl auristatin E intermediate-3 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-43147

Monomethyl auristatin E intermediate-4	Others	Cancer
Monomethyl auristatin E intermediate-4 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-43149

Monomethyl auristatin E intermediate-5	Others	Cancer
Monomethyl auristatin E intermediate-5 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-49413

Monomethyl auristatin E intermediate-2	Others	Cancer
Monomethyl auristatin E intermediate-2 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-78899

Monomethyl auristatin E intermediate-6	Others	Cancer
Monomethyl auristatin E intermediate-6 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-78901

Monomethyl auristatin E intermediate-7	Others	Cancer
Monomethyl auristatin E intermediate-7 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-78901A

Monomethyl auristatin E intermediate-8	Others	Cancer
Monomethyl auristatin E intermediate-8 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-78903

Monomethyl auristatin E intermediate-9	Others	Cancer
Monomethyl auristatin E intermediate-9 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-78903A

Monomethyl auristatin E intermediate-10	Others	Cancer
Monomethyl auristatin E intermediate-10 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-78908

Monomethyl auristatin E intermediate-11	Others	Cancer
Monomethyl auristatin E intermediate-11 is an intermediate reactant in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-78910

Monomethyl auristatin E intermediate-12	Others	Cancer
Monomethyl auristatin E intermediate-12 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-78911

Monomethyl auristatin E intermediate-13	Others	Cancer
Monomethyl auristatin E intermediate-13 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-78913

Monomethyl auristatin E intermediate-14	Others	Cancer
Monomethyl auristatin E intermediate-14 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-79196

Monomethyl auristatin E intermediate-15	Others	Cancer
Monomethyl auristatin E intermediate-15 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-79198

Monomethyl auristatin E intermediate-16	Others	Cancer
Monomethyl auristatin E intermediate-16 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-79205

Monomethyl auristatin E intermediate-17	Others	Cancer
Monomethyl auristatin E intermediate-17 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-Y1097

Monomethyl phthalate 2-(Methoxycarbonyl)benzoic acid
Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule .

HY-N3056

Pinosylvin monomethyl ether

Bacterial Fungal Infection

Pinosylvin monomethyl ether has antibacterial effect and fungicidal activity .
HY-N3247

Monomethyl kolavate

Parasite Others

Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC₅₀ value of 2 µM .
HY-N3420

Koaburaside monomethyl ether

Others Cancer

Koaburaside monomethyl ether is a phenolic glycoside that can be isolated from Averrhoa carambola L. .
HY-W018365

Tetraethylene glycol monomethyl ether

PROTAC Linkers Cancer

Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
HY-120175

Nonaethylene glycol monomethyl ether

PROTAC Linkers Cancer

Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
HY-W042625

Hexaethylene glycol monomethyl ether

PROTAC Linkers Cancer

Hexaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
HY-W042657

Octaethylene glycol monomethyl ether

PROTAC Linkers Cancer

Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
HY-W042713

Pentaethylene glycol monomethyl ether

PROTAC Linkers Cancer

Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

*Pinosylvin monomethyl* ether**	Bacterial Fungal	Infection
Pinosylvin monomethyl ether has antibacterial effect and fungicidal activity .

Monomethyl kolavate	Parasite	Others
Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC₅₀ value of 2 µM .

*Koaburaside monomethyl* ether**	Others	Cancer
Koaburaside monomethyl ether is a phenolic glycoside that can be isolated from Averrhoa carambola L. .

*Tetraethylene glycol monomethyl* ether**	PROTAC Linkers	Cancer
Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

*Nonaethylene glycol monomethyl* ether**	PROTAC Linkers	Cancer
Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

*Hexaethylene glycol monomethyl* ether**	PROTAC Linkers	Cancer
Hexaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

*Octaethylene glycol monomethyl* ether**	PROTAC Linkers	Cancer
Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

*Pentaethylene glycol monomethyl* ether**	PROTAC Linkers	Cancer
Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-15162G

Monomethyl auristatin E MMAE; SGD-1010; Vedotin	Microtubule/Tubulin Apoptosis ADC Cytotoxin	Cancer
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .

HY-Y1097S

Monomethyl phthalate-d4 2-(Methoxycarbonyl)benzoic acid-d₄	Isotope-Labeled Compounds	Cancer
Monomethyl phthalate-d₄ (2-(Methoxycarbonyl)benzoic acid-d₄) is the deuterium labeled Monomethyl phthalate. Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule .

HY-126492

*Vat-Cit-PAB-Monomethyl* Dolastatin 10**	Drug-Linker Conjugates for ADC	Cancer
Vat-Cit-PAB-Monomethyl Dolastatin 10 is a agent-linker conjugate for ADC with potent antitumor activity by using Monomethyl Dolastatin 10 (a potent tubulin inhibitor), linked via the ADC linker Vat-Cit-PAB.

HY-78899A

*(4R,5S)-Monomethyl* auristatin E intermediate-6**	Others	Cancer
(4R,5S)-Monomethyl auristatin E intermediate-6 is an intermediate reagent in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs) .

HY-N7982

*(+)-Pinoresinol monomethyl* ether O-β-D-glucoside**	Others	Others
(+)-Pinoresinol monomethyl ether O-β-D-glucoside (Compound 6) is a natural product that can be isolated from the stems of Tinospora sinensis .

HY-134990

*Hematoporphyrin monomethyl* ether** 1 Publications Verification	Apoptosis	Cancer
Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and research of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma .

HY-15162

Monomethyl auristatin E 35+ Cited Publications MMAE; SGD-1010; Vedotin	Microtubule/Tubulin ADC Cytotoxin Apoptosis	Cancer
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

HY-141218

m-PEG10-alcohol Decaethylene glycol Monomethyl ether	ADC Linker PROTAC Linkers	Cancer
m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-78931

Boc-Dap-NE	ADC Linker	Cancer
Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-W013863

Djalonensone Alternariol Monomethyl ether	Antibiotic Bacterial	Others
Djalonensone, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species .

HY-N0829

Shionone	Others	Inflammation/Immunology
Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .

HY-78931G

Boc-Dap-NE	ADC Linker	Cancer
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-79256

MMAF-OMe 1 Publications Verification Monomethyl auristatin F methyl ester	ADC Cytotoxin	Cancer
MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC₅₀s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4 ^-) cell lines, respectively.

HY-78932

Dap-NE

Others Cancer

Dap-NE is an intermediate reagent in the synthesis of the ADC toxin Monomethyl auristatin E (HY-15162) .

HY-78931C

(S,S,R,S,R)-Boc-Dap-NE	Others	Cancer
(S,S,R,S,R)-Boc-Dap-NE is an isomer of the dipeptide Boc-Dap-NE (HY-78931). Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

Cat. No.	Product Name	Type

HY-15162G

Monomethyl auristatin E (GMP) MMAE (GMP); SGD-1010 (GMP); Vedotin (GMP)	Fluorescent Dye
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .

HY-78931G

Boc-Dap-NE (GMP)	Fluorescent Dye
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-78738G

MC-Val-Cit-PAB (GMP)	Fluorescent Dye
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

Cat. No.	Product Name	Type

HY-15162G

Monomethyl auristatin E (GMP) MMAE (GMP); SGD-1010 (GMP); Vedotin (GMP)	Biochemical Assay Reagents
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .

HY-78931G

Boc-Dap-NE (GMP)	Biochemical Assay Reagents
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-78738G

MC-Val-Cit-PAB (GMP)	Biochemical Assay Reagents
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

HY-140696C

m-PEG-OH (MW 20000)

mPEG-Hydroxy (MW 20000); Polyethylene glycol Monomethyl ether (MW 20000)

Drug Delivery

m-PEG-OH (MW 20000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Nanoscale micelles can be prepared by using amphiphilic block copolymers to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.

HY-140696D

m-PEG-OH (MW 10000)

mPEG-Hydroxy (MW 10000); Polyethylene glycol Monomethyl ether (MW 10000)

Drug Delivery

m-PEG-OH (MW 10000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.

HY-140696E

m-PEG-OH (MW 1000)

mPEG-Hydroxy (MW 1000); Polyethylene glycol Monomethyl ether (MW 1000)

Drug Delivery

m-PEG-OH (MW 1000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Amphiphilic block copolymers can be used to prepare nanoscale micelles to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger cancer-killing activity than free Paclitaxel. And it accumulates preferentially in tumor tissues and has only limited distribution in healthy organs.

Cat. No.	Product Name	Target	Research Area

HY-W142140

N-Methyl-DL-valine N-Methylvaline	Amino Acid Derivatives	Others
N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .

Cat. No.	Product Name	Target	Research Area

HY-P99956

Zilovertamab vedotin VLS-101; MK-2140	Antibody-Drug Conjugates (ADCs) Apoptosis	Cancer
Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces apoptosis. Zilovertamab vedotin can be used in research of cancer .

HY-P99970

Lifastuzumab	ADC Antibody	Others
Lifastuzumab is a humanized anti-NaPi2b monoclonal antibody (IgG1 type). Lifastuzumab can be coupled with monomethyl auristatin E (MMAE) through ADC Linker to form an antibody-drug conjugate (ADC) lifastuzumab vedotin (DNIB0600A) with anticancer activity .

HY-P99205

Glembatumumab	ADC Antibody	Cancer
Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .

HY-132253

Polatuzumab vedotin	Antibody-Drug Conjugates (ADCs)	Cancer
Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. Polatuzumab vedotin has the potential for the research of Large B-cell lymphomas (LBCL) .

HY-P99593A

Sofituzumab vedotin (solution) DMUC5754A (solution)	Antibody-Drug Conjugates (ADCs)	Cancer
Sofituzumab vedotin (DMUC5754A) (solution) is an antibody-drug conjugate (ADC) that contains the humanized IgG1 anti-MUC16 monoclonal antibody and a potent anti-mitotic agent, monomethyl auristatin E (MMAE), linked through a protease-cleavable linker .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6904

*Crocetin monomethyl* ester**	Structural Classification Neurological Disease Classification of Application Fields Terpenoids Source classification Diterpenoids Lridaceae Plants Crocus sativus L. Inflammation/Immunology Disease Research Fields	Amyloid-β
Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity . Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway .

HY-N3056

*Pinosylvin monomethyl* ether**	Infection Monophenols other families Stilbenes Classification of Application Fields Source classification Phenols Plants Disease Research Fields	Bacterial Fungal
Pinosylvin monomethyl ether has antibacterial effect and fungicidal activity .

HY-N8931

Monomethyl lithospermate Lithospermic acid Monomethyl ester	Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants	Akt
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS) .

HY-N3754

*Dihydropinosylvin monomethyl* ether**	Infection Monophenols Classification of Application Fields Pinaceae Source classification Pinus pumila (Pall.) Regel Phenols Plants Disease Research Fields	Parasite
Dihydropinosylvin monomethyl ether is a natrual compound with nematicidal activity. Dihydropinosylvin monomethyl ether can inhibit pine wood nematodes infection .

HY-N3247

Monomethyl kolavate	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Inula grandis Schrenk ex Fish..	Parasite
Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC₅₀ value of 2 µM .

HY-N3420

*Koaburaside monomethyl* ether**	Structural Classification Natural Products Source classification Averrhoa carambola L. Plants Oxalidaceae	Others
Koaburaside monomethyl ether is a phenolic glycoside that can be isolated from Averrhoa carambola L. .

HY-N7982

*(+)-Pinoresinol monomethyl* ether O-β-D-glucoside**	Structural Classification Source classification Plants Menispermaceae Saccharides Tinospora sinensis (Lour.) Merr. Monosaccharides	Others
(+)-Pinoresinol monomethyl ether O-β-D-glucoside (Compound 6) is a natural product that can be isolated from the stems of Tinospora sinensis .

HY-W013863

Djalonensone Alternariol Monomethyl ether	Structural Classification other families Classification of Application Fields Source classification Other Diseases Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields	Antibiotic Bacterial
Djalonensone, isolated from the roots of Anthocleista djalonensis (Loganiaceae), is an important taxonomic marker of the plant species .

HY-N0829

Shionone	Structural Classification Classification of Application Fields Terpenoids Diterpenoids Plants Compositae Inflammation/Immunology Disease Research Fields Sesbania vesicaria (Jacq.) Elliott	Others
Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .

HY-111811

Homomangiferin	other families Xanthones Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Others
Homomangiferin is mangiferin monomethyl ether. Homomangiferin has important medicinal properties and is widely used to relieve many symptoms, for example coughing and asthma .

Cat. No.	Product Name	Chemical Structure

HY-103252S

Monomethyl fumarate-d3 1 Publications Verification
Monomethyl fumarate-d₃ is a deuterium labeled Monomethyl fumarate. Monomethyl fumarate is the primary metabolite of dimethyl fumarate[1].

HY-Y1097S

Monomethyl phthalate-d4
Monomethyl phthalate-d₄ (2-(Methoxycarbonyl)benzoic acid-d₄) is the deuterium labeled Monomethyl phthalate. Monomethyl phthalate is a phthalate metabolite. Monomethyl phthalate acts as a urinary biomarker of phthalates exposure and can be used as a standard for the determination of thyroid cancer and benign nodule .

HY-15162A

MMAE-d8

5+ Cited Publications

MMAE-d₈ is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor.

HY-103252S1

Monomethyl fumarate-d5
Monomethyl fumarate-d₅ is deuterium labeled Monomethyl fumarate. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].

HY-144182S

Metoxuron-monomethyl-d3

Metoxuron-monomethyl-d₃ is the deuterium labeled Metoxuron-monomethyl[1].

HY-15575S

VcMMAE-d8
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .

HY-15581S

MMAD-d8

MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

Cat. No.	Product Name	Application	Reactivity

HY-P81056

MMAE Antibody (YA899) MMAE; Monomethyl auristatin E; Monomethylauristatin E; Monomethylauristatin norephedrine; Toxin MMAE; MMAE toxin	ELISA；	Species independent
MMAE Antibody (YA899) is an unconjugated, rabbit-derived, anti-MMAE (YA899) monoclonal antibody. MMAE Antibody (YA899) can be used for: ELISA, Sandwich ELISA, Competitive ELISA expriments in background without labeling.

HY-P81057

MMAF Antibody (YA900) Monomethylauristatin F, Monomethyl Auristatin F, 745017-94-1	ELISA; Sandwich ELISA; Competitive ELISA
MMAF Antibody (YA900) is an unconjugated, mouse-derived, anti-MMAF (YA900) monoclonal antibody. MMAF Antibody (YA900) can be used for: ELISA, Sandwich ELISA, Competitive ELISA expriments in background without labeling.

HY-P81287A

MonoMethyl-Histone H3 Antibody (YA998)

H3K14me; H3.4; H3/g; H3FT; H3t
WB, ICC/IF Human, Mouse
HY-P81287

MonoMethyl-Histone H3 Antibody (YA997)

H3K79me; H3 histone; HIST1H3A; Histone cluster 1; H3a
WB, IHC-P Human, Mouse, Rat
HY-P83301

MonoMethyl-Histone H4 Antibody (YA3046)

H4K16me; H4; H4/n; H4F2; H4FN; FO108; HIST2H4
WB, ICC/IF Human, Mouse

Cat. No.	Product Name		Classification

HY-126690

DBCO-(PEG2-VC-PAB-MMAE)2		DBCO
DBCO-(PEG2-VC-PAB-MMAE)2 is made by MMAE conjugated to the cleavable DBCO-(PEG2-VC-PAB)2 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody agent conjugate . DBCO-(PEG2-VC-PAB-MMAE)2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-111012

DBCO-(PEG)3-VC-PAB-MMAE 1 Publications Verification		DBCO
DBCO-(PEG)3-VC-PAB-MMAE is a agent-linker conjugate for ADC. DBCO-(PEG)3-VC-PAB-MMAE is made by Monomethyl auristatin E (HY-15162) conjugats to DBCO-(PEG)3-vc-PAB linker. DBCO-(PEG)3-VC-PAB-MMAE can be used for the research of cancer . DBCO-(PEG)3-VC-PAB-MMAE is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-W190943

Azido-PEG4-Val-Cit-PAB-MMAE		Azide
Azido-PEG4-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the cleavable linker Azido-PEG4-Val-Cit-PAB-OH . Azido-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Monomethyl fumarate

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Natural
Products